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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALDH1A1 All Species: 43.33
Human Site: S261 Identified Species: 86.67
UniProt: P00352 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00352 NP_000680.2 501 54862 S261 I K E A A G K S N L K R V T L
Chimpanzee Pan troglodytes XP_001143226 476 52240 T248 K V A F T G S T E V G K L I K
Rhesus Macaque Macaca mulatta XP_001097512 501 54782 S261 I K E A A G K S N L K R V T L
Dog Lupus familis XP_533525 501 54927 S261 I K E A A G K S N L K R V T L
Cat Felis silvestris
Mouse Mus musculus P24549 501 54449 S261 I K E A A G K S N L K R V T L
Rat Rattus norvegicus P51647 501 54440 S261 I K E A A G K S N L K R V T L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506070 601 66397 S361 I K E A A G K S N L K R V T L
Chicken Gallus gallus P27463 509 55791 T269 I K E A A G K T N L K R V T L
Frog Xenopus laevis Q6GNL7 902 99964 S665 I M K S C A V S N V K K V S L
Zebra Danio Brachydanio rerio NP_571925 518 56497 S278 I Q E A A G K S N L K R V T L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SU63 538 58570 S297 I L G L A A N S N L K P V T L
Baker's Yeast Sacchar. cerevisiae P32872 511 56448 S289 V M K A A A K S N L K K V T L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95 98.8 89 N.A. 87 86.4 N.A. 72.5 82.5 29.8 70 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 95 99.1 95 N.A. 94.4 94 N.A. 79.6 90.3 40.3 81.4 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 100 93.3 40 93.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 33.3 100 100 N.A. 100 100 N.A. 100 100 73.3 100 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 52.9 60.2 N.A.
Protein Similarity: N.A. N.A. N.A. 67.8 70.6 N.A.
P-Site Identity: N.A. N.A. N.A. 60 66.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 75 84 25 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 67 0 0 0 0 0 9 0 0 0 0 0 0 % E
% Phe: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 0 0 75 0 0 0 0 9 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 84 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % I
% Lys: 9 59 17 0 0 0 75 0 0 0 92 25 0 0 9 % K
% Leu: 0 9 0 9 0 0 0 0 0 84 0 0 9 0 92 % L
% Met: 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 9 0 92 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % P
% Gln: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 67 0 0 0 % R
% Ser: 0 0 0 9 0 0 9 84 0 0 0 0 0 9 0 % S
% Thr: 0 0 0 0 9 0 0 17 0 0 0 0 0 84 0 % T
% Val: 9 9 0 0 0 0 9 0 0 17 0 0 92 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _